Important Announcement: Journal status update, Garuda indexation, and the separation of OJS systems.
Ninna Rohmawati
Bagian Gizi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat Universitas Jember
Emi Wuri Wuryaningsih
Departemen Keperawatan Jiwa dan Komunitas Program Studi Ilmu Keperawatan Universitas Jember
DOI:
Keywords: Red fruit oil, total cholesterol content, aterogenic diet
ABSTRACT
Cardiovascular Disease (CVD) serves as the main cause of death in the world. The controllable main risk factor in Coronary Heart Disease (CHD) is LDL cholesterol content, triglyserida, and HDL cholesterol content in blood. The attempt to control coronary heart disease is by using antioxidant. Antioxidant can obstruct oxidation process and neutralize free radical to prevent various degenerative disease. This study was intended to find out the effect of red fruit oil (Pandanus conoideus oil) toward total cholesterol content of rat (Rattus novergicus strain wistar) with Aterogenic diet. This study was an experimental study. The design applied was complete randomized design with 3 repetitions and 8 treatment levels, namely P0 (diet standard), P1 (Aterogenic diet), P2 (S + MBM 0,12 ml/day), P3 (S + MBM 0,24 ml/day), P4 (S + MBM 0,36 ml/day), P5 (A + MBM 0,12 ml/day), P6 (A + MBM 0,24 ml/day), P7 (A + MBM 0,36 ml/day). The parameter was total cholesterol content. The process and data analysis applied Oneway Anova statistical test and followed with DMRT (Duncan Multiple Range Test). The result of Oneway Anova statistical test in confidence level 99% indicated that there was variance of significant total cholesterol content (p=0,000) among every treatment levels. The effect of using red fruit oil (Pandanus conoideus oil) toward total cholesterol content of rat (Rattus novergicus strain wistar) with aterogenic diet effective in 0,12 ml/day. The conclusion inferred from this study indicated that using red fruit oil (Pandanus conoideus oil) has significant effect toward reduction of total cholesterol content of rat (Rattus novergicus strain wistar) with aterogenic diet.
REFERENCES
A Staff of Twenty Nine Contributors, edited by: Edmond J. Farris, Ph.D, John Q. Griffith, Jr.M.D. 1971. The Rat In Laboratory Investigation. Hafner Publishing Company. New York.
Agustina, R. 2003. Antioksidan, Penemuan Revolusioner bagi Kesehatan. Gizi Medik Indonesia. Vol 2 no 5, April 2003.
Andi Nur Alamsyah. 2005. Perpaduan Sang Penakluk Penyakit VCO + Buah Merah. PT Agromedia Pustaka. Jakarta.
Bandawati. 2008. Pengaruh Minyak Buah Merah terhadap Penurunan Kadar LDL dan Peningkatan HDL pada Tikus Wistar. Jurusan Ilmu Gizi Kesehatan, Fakultas Kedokteran Universitas Brawijaya. Malang.
Boileau. 1998. Chemistry of Oxygen Species and Antioxidants in Papas A (Ed), Status, Diet, Nutrition and Health, CRC Press. Boca Raton London New York Washington DC.
Chandrasoma, P. Taylor, CR. 2006. Ringkasan Patologi Anatomi E/2. Roem Soedoko, Lydia I, Mandera, Vivi S (Penterjemah). Penerbit Buku Kedokteran EGC. Jakarta.
Elin Yulinah, Suwendar, I Ketut Adnyana. 2005. Uji Aktivitas Antiinflamasi Minyak Buah Merah (Pandanus conoideus lamk.) pada Tikus Wistar Betina. Acta Pharmaceutica Indonesia. Vol 30 (2005) No. 3 Hal. 76-79
Gordon and Margareth. 2002. Perspective in Nutrition. New York. Mc Graw Hill. p.88
Gotto Antonio M., Ellison H. Wittels. 1994. Diet Kolesterol, Lipoprotein Serum dan Penyakit Jantung Koroner dalam Pencegahan Penyakit Jantung Koroner, Kaplar Stamler (ed), terjemahan Sukwan Hamdali, EGC, Jakarta.
Guyton, 1994, Fisiologi Kedokteran Edisi 9, EGC Penerbit Buku Kedokteran, Jakarta.
Kemas Ali Hanafiah. 2005. Rancangan Percobaan Teori dan Aplikasi. Raja Grafindo Persada. Jakarta.
Kochher dan Rossel. 1990. Detection Estimation and Evaluation of Antioxidants in Food System. Didalam: B. J. Hudson. Editor Food Antioxidant. Eluiseer Applied Science. London.
Lori, AS dan Mary, BC. 1994. Nutrition Science and Aplication. Saunders Collage Publishing. Florida.
Montgomery, R., Robert, L., Thomas, W. C., and Arthur, A. S. 1993. Biokimia Suatu Pendekatan Berorientasi Kasus, edisi keempat, Alih bahasa M. Ismadi. Yogyakarta, Indonesia: Gadjah Mada Universitas Press.
Mulyohadi Ali, Sri Murwani, Ketut Muliartha. 2006. Diet Aterogenik pada Tikus Putih (Rattus novergicus strain wistar) Sebagai Model Hewan Aterosklerosis dalam Jurnal Kedokteran Brawijaya, vol. XXII. No. 1. April 2006, hal 7-9.
Mun'im, Retnosari A, Heni S. Uji Hambatan Tumorigenesis Sari Buah Merah (Pandanus conoideus Lam) Terhadap Tikus Putih Betina yang Diinduksi 7,12 DimetilBenz(a)Antrasen (DMBA). Majalah Ilmu Kefarmasian. 2006. 111. (3): 153-161.
Noguchi N and Etsuo Niki. 1998. Chemistry of Oxygen Species and Antioxidants in Papas A (Ed), Status, Diet, Nutrition and Health, CRC Press. Boca Raton London New York wasington DC. P.3-19.
Papas, Andreas M. 1998. Antioxidant, Status, Diet, Nutririon, and Health. CRC Press. Boca Raton London New York Washington, DC.
Pritchett, K.R and Corning B.1. 2004. Biology and Medicine of Rats International Veterinary Information Service. Ithaca New York.
Purwanto, A. 2001. Efek Gizi Tempe terhadap Hiperlipidemia Penderita Rawat Jalan. www.health-Irc.or.id.
Steel, Robert. GD and Torrie, James H. 1993. Prinsip dan Prosedur Statistika, Suatu Pendekatan Biometrik. PT Gramedia Pustaka Utama. Jakarta.
Sudigdo Sastroasmoro dan Sofyan Ismael 1995. Dasar-dasar Metodologi Penchtian Klinik Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia Jakarta
Sunita Almatsior, 2001 Prinsip Dasar Ilmu Gizi, edtsi baru. PT Gramedia Pustaka Utama Jakarta
Supardan, 2001, Metabolisme Lemak, Laboratorium Biokimia Fakultas Kedokteran Universitas Brawijaya Malang.
Syarkiah. 2008. Pengaruh Pemberian Minyak Buah Merah (Pandanus conoideus oll) terhadap Pembentukan Foam Cell pada Tikus Galur Wistar (Rattus novergicus) dengan Diet Aterogenik. Jurusan Ilmu Gizi Kesehatan, Fakultas Kedokteran Universitas Brawijaya. Malang.
Tierney Jr, McPhee, Papadakis. 2002. Diagnosis dan Terapi Kedokteran, IPD. Abdul Gofir (penterjemah). Salemba Medika. Jakarta. hal. 242-243.
Whitney, Ellie and Roflfes, Sharon Rady. 2005. Understanding Nutrition-Tenth Edition. Thomsom-Wadsworth. USA. p. 620-629.
Yahya, M, Wahyu W. 2005. Khasiat dan Manfaat Buah Merah: si emas merah dari papua. PT Agromedia Pustaka. Jakarta.
Yayasan Jantung Indonesia. 2005. Seperempat Abad Yayasan Jantung Indonesia. Diakses 03 Januari 2008, http://www.depkes.go.id
